LANDSCAPE OF HUMAN ORGANOIDS: IDEAL MODEL IN CLINICS AND RESEARCH

Landscape of human organoids: Ideal model in clinics and research

In the last decade, organoid research has entered a golden era, signifying a pivotal shift in the biomedical landscape.The year 2023 marked a milestone with the publication of thousands of papers in this arena, reflecting exponential growth.However, amid this burgeoning expansion, a comprehensive and accurate overview of the field has been conspicu

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Safety, Tolerability, and Dose-Limiting Toxicity of Lacosamide in Patients With Painful Chronic Pancreatitis: Protocol for a Phase 1 Clinical Trial to Determine Safety and Identify Side Effects

BackgroundChronic abdominal pain is the hallmark symptom of chronic pancreatitis (CP), with 50% to 80% of patients seeking medical attention for pain control.Although several management options are available, outcomes are often disappointing, and opioids remain a mainstay of therapy.Opioid-induced hyperalgesia is a phenomenon resulting in dose esca

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To study the effect of Cocos nucifera oil when incorporated into tissue conditioner on its tensile strength and antifungal activity: An in vitro study

Aim: This study aims to test the tensile strength and growth of Candida albicans on Viscogel tissue conditioner when incorporated with coconut oil (CCO) and to compare its efficacy with other antifungal agents.Settings and Design: Evaluative - In-vitro study design.Materials and Methods: Fifty dumbbell-shaped samples (n = 10) of Viscogel tissue con

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Most published meta-regression analyses based on aggregate data suffer from methodological pitfalls: a meta-epidemiological study

Abstract Background Due to clinical and methodological diversity, clinical studies included in meta-analyses often differ in ways that lead to differences in treatment effects across studies.Meta-regression analysis is generally recommended to explore associations between study-level characteristics and treatment effect, however, three key pitfalls

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Maximizing Energy Content and CO2 Bio-fixation Efficiency of an Indigenous Isolated Microalga Parachlorella kessleri HY-6 Through Nutrient Optimization and Water Recycling During Cultivation

An alternative source of energy and materials with low negative environmental impacts is essential for a sustainable future.Microalgae is a promising candidate in this aspect.The focus of this study is to optimize the supply of nitrogen and carbon mh6336gih dioxide during the cultivation of locally isolated strain Parachlorella kessleri HY-6.This s

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